He says, 'Previous research on the subject indicates that tissue absorption and scattering could contribute up to 45 percent variation in the detected Cherenkov emission between patients imaged. Pogue currently leads teams at Dartmouth and the University of Wisconsin–Madison that aim to make Cherenkov imaging a reliable indicator of radiation doses. This means that the Cherenkov radiation signal from human tissue is not accurately interpretable as proportional to dose. However in reality, tissue attenuation reduces the intensity of emitted Cherenkov radiation, altering the otherwise linear relationship between the dose deposited and the observed Cherenkov emission.

In an ideal scenario where no Cherenkov is absorbed or scattered by the tissue, the emitted light is directly proportional to the incident radiation dose, allowing for accurate detection of the radiation dose delivered to the tissue from the emitted Cherenkov signal. These soft collision-type interactions lead to electromagnetic shifts in the molecules that release Cherenkov radiation when returning to their original state, which can be detected and correlated to the amount of deposited dose from the radiation. As high-energy charged particles from the incident radiation pass through biological tissue, either as primary or secondary radiation, they interact with the electromagnetic fields of the atoms and molecules in the tissue. This imaging technique works by detecting Cherenkov radiation, which is emitted by tissues exposed to high-energy radiation, such as X-rays or electron beams from a linear accelerator. Mar 14 2023Ĭherenkov imaging is a valuable cancer treatment tool that can help doctors track and monitor radiation doses received by tissues during cancer therapy in real time.

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